Control of Retinal Sensitivity : II. Lateral Interactions at the Outer Plexiform Layer

Test stimuli, presented at the center of the bipolar cell receptive field, spanning less than 2 log units of intensity, elicit the full range of graded response. The intensity range of test stimuli that elicits the graded response depends upon the background conditions. A higher range of log test intensities is required to elicit the graded bipolar response in the presence of surround backgrounds. But surround backgrounds can also serve to unsaturate the bipolar response and thereby increase sensitivity under certain conditions. The results suggest that a second stage of sensitivity-control is mediated by the horizontal cell system at the outer plexiform layer, concatenated with the effects of adaptation in the photoreceptors

Control of Retinal Sensitivity : I. Light and Dark Adaptation of Vertebrate Rods and Cones

Rods and cones in Necturus respond with graded hyperpolarization to test flashes spanning about 3.5 log units of intensity. Steady background levels hyperpolarize the rods, and the rod responses become progressively smaller as background level is increased. In cones, higher background levels reduce the effectiveness of test flashes, so higher ranges of test intensities are required to elicit the full range of graded responses. When backgrounds are terminated, cones return rapidly, but rods return slowly to the dark potential level. The effects of backgrounds on both rods and cones can be observed at intensities that cause negligible bleaching as determined by retinal densitometry. During dark adaptation, changes are observed in the rods and cones that are similar to those produced by backgrounds. Receptor sensitivities, derived from these results, show that rods saturate, cones obey Weber's law, and sensitization during dark adaptation follows a two-phase time-course

Bioinspired engineering of exploration systems for NASA and DoD

A new approach called bioinspired engineering of exploration systems (BEES) and its value for solving pressing NASA and DoD needs are described. Insects (for example honeybees and dragonflies) cope remarkably well with their world, despite possessing a brain containing less than 0.01% as many neurons as the human brain. Although most insects have immobile eyes with fixed focus optics and lack stereo vision, they use a number of ingenious, computationally simple strategies for perceiving their world in three dimensions and navigating successfully within it. We are distilling selected insect-inspired strategies to obtain novel solutions for navigation, hazard avoidance, altitude hold, stable flight, terrain following, and gentle deployment of payload. Such functionality provides potential solutions for future autonomous robotic space and planetary explorers. A BEES approach to developing lightweight low-power autonomous flight systems should be useful for flight control of such biomorphic flyers for both NASA and DoD needs. Recent biological studies of mammalian retinas confirm that representations of multiple features of the visual world are systematically parsed and processed in parallel. Features are mapped to a stack of cellular strata within the retina. Each of these representations can be efficiently modeled in semiconductor cellular nonlinear network (CNN) chips. We describe recent breakthroughs in exploring the feasibility of the unique blending of insect strategies of navigation with mammalian visual search, pattern recognition, and image understanding into hybrid biomorphic flyers for future planetary and terrestrial applications. We describe a few future mission scenarios for Mars exploration, uniquely enabled by these newly developed biomorphic flyers

The retinal hypercircuit: a repeating synaptic interactive motif underlying visual function

The vertebrate retina generates a stack of about a dozen different movies that represent the visual world as dynamic neural images or movies. The stack is embodied as separate strata that span the inner plexiform layer (IPL). At each stratum, ganglion cell dendrites reach up to read out inhibitory interactions between three different amacrine cell classes that shape bipolar-to-ganglion cell transmission. The nexus of these five cell classes represents a functional module, a retinal 'hypercircuit', that is repeated across the surface of each of the dozen strata that span the depth of the IPL. Individual differences in the characteristics of each cell class at each stratum lead to the unique processing characteristics of each neural image throughout the stack. This review shows how the interactions between the morphological and physiological characteristics of each cell class generate many of the known retinal visual functions including motion detection, directional selectivity, local edge detection, looming detection, object motion and looming detection

The retinal hypercircuit: a repeating synaptic interactive motif underlying visual function.

The vertebrate retina generates a stack of about a dozen different movies that represent the visual world as dynamic neural images or movies. The stack is embodied as separate strata that span the inner plexiform layer (IPL). At each stratum, ganglion cell dendrites reach up to read out inhibitory interactions between three different amacrine cell classes that shape bipolar-to-ganglion cell transmission. The nexus of these five cell classes represents a functional module, a retinal 'hypercircuit', that is repeated across the surface of each of the dozen strata that span the depth of the IPL. Individual differences in the characteristics of each cell class at each stratum lead to the unique processing characteristics of each neural image throughout the stack. This review shows how the interactions between the morphological and physiological characteristics of each cell class generate many of the known retinal visual functions including motion detection, directional selectivity, local edge detection, looming detection, object motion and looming detection

Synaptic inputs to the ganglion cells in the tiger salamander retina.

The postsynaptic potentials (PSPs) that form the ganglion cell light response were isolated by polarizing the cell membrane with extrinsic currents while stimulating at either the center or surround of the cells receptive field. The time-course and receptive field properties of the PSPs were correlated with those of the bipolar and amacrine cells. The tiger salamander retina contains four main types of ganglion cell: on center, off center, on-off, and a hybrid cell that responds transiently to center, but sustainedly, to surround illumination. The results lead to these inferences. The on-ganglion cell receives excitatory synpatic input from the on bipolars and that synapse is silent in the dark. The off-ganglion cell receives excitatory synaptic input from the off bipolars with this synapse tonically active in the dark. The on-off and hybrid ganglion cells receive a transient excitatory input with narrow receptive field, not simply correlated with the activity of any presynaptic cell. All cell types receive a broad field transient inhibitory input, which apparently originates in the transient amacrine cells. Thus, most, but not all, ganglion cell responses can be explained in terms of synaptic inputs from bipolar and amacrine cells, integrated at the ganglion cell membrane

Temporal and Spatial Dependence of Adaptation on Ganglion Cells

One of the visual system’s many tasks is to be able to distinguish objects from the background. The ability to do this is limited and affected by the relationship between the object (or stimulus) of interest and the background. Adaptation in retinal neurons is the process of changing the cell’s response to a stimulus according to that stimulus’s background. When the stimulus is hard to discern from the background, the retina adapts by improving its sensitivity to low contrast. The large response range maintained by adaptation comes at a cost, however. Adaptation complicates neural coding by making the brain interpret identical stimuli as different based on differences in background. In order to further our understanding of adaptation, this study modified the background to be in terms of time and space rather than light intensity as is the norm. By changing the interval between two circular stimuli (inter-stimuli interval; IsI) of the same diameter, and by changing the diameter over a common IsI, we measured a ganglion cell’s output for one stimulus relative to another stimulus. the results show saturation (loss of output to the 2nd stimulus) of stimuli at lower IsIs. Also, the degree of saturation for a given IsI depends on the diameter of the stimulus. These combinations of results illustrate the temporal and spatial dependence of adaptation on ganglion cells. A larger-diameter stimulus involves multiple neurons surrounding the ganglion cell being recorded so various pathways most likely influence that cell’s ultimate output. Rapid stimuli (low IsI) can be defined as having large mean luminosity that directly affects ganglion cell output